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HKII+/− hearts have lower function and increased cell death after I/R ex vivo. HKII+/− hearts display a higher degree of LDH release and cell injury (A), no change in the rate pressure product (B), a higher end diastolic pressu re (C), and no change in DLVP (D). LDH release and RPP were measured during 60 min reperfusion following 40 min ischemia. EDP was assessed at baseline and after 60 minutes of reperfusion. *P < 0.05, n = 6. Data are presented as mean ± SEM.
