Table 1.
The role of cyclin D in several types of cancers
| Parathyroid adenomas | Cyclin D overexpression in both neoplastic and non- neoplastic proliferating parathyroid tissue. |
|---|---|
| Papillary thyroid carcinoma | lymph node metastasis |
| Mantle cell lymphoma | Higher age distribution Larger cell size Higher mitotic index More frequent gastrointestinal involvement Higher international prognostic index score Lower p27 expression Significantly worse survival |
| breast cancer | higher tumour grade no correlation with axillary lymph node status or tumour size or HER2 amplification poorer prognosis indication for need for additional chemotherapeutic treatment positive correlation with ER status (p < 0.005) positive correlation with PR status (p < 0.005) inverse correlation to Nottingham prognostic index inverse correlation to membrane EGFR significantly shorter overall survival and relapse - free survival tamoxifen resistance |