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Affinity of sorafenib for BCRP. The B-to-A permeability of sorafenib was determined in MDCKII-Bcrp1 cells, with a range of concentrations (0.001 nM to 80 nM) applied to the donor side. A sigmoid inhibitory Emax model was fitted to the data and the affinity constant (Kmapp) was determined to be 5 nM (●, observed data; dashed line, model predicted curve. Mean ± S.D. (n = 3); parameter estimate reported as mean ± S.D. (standard error of the estimate).
