Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Apparent permeability of [3H]sorafenib across MDCKII wild-type and Bcrp1-transfected cell monolayers. In the Bcrp transfects, the B-to-A permeability (gray bar) was significantly greater than the A-to-B permeability (black bar). Treatment with Ko143 decreased the B-to-A permeability. No difference in apparent permeability was observed in the wild-type cells. Mean ± S.D. (n = 6). *, p < 0.05.
