Figure 14. Hemichannel blockers do not affect the respiratory response to systemic hypoxia in vivo.
A, neither proadifen (PA, 200 μm) nor NPPB (200 μm) altered the increases in phrenic nerve activity (PNG – integrated phrenic neurogram) evoked by 5 min of 10% hypoxia (thick bars) in an anaesthetized and ventilated rat. The combination of both agents had no effect either. (n = 4 rats.) B, changes in phrenic nerve amplitude in response to hypoxia under control conditions and in the presence of the hemichannel blockers.