Table 3.
Grade 2 and above Treatment-Related Toxicity during Chemoradiation.
| Toxicity | Toxicity Events by Dose Level | ||||
| DL 1 (n = 7) | DL -1 (n = 6) | ||||
| Grade 2 | Grade 3,4 | Grade 2 | Grade 3,4 | ||
| Nonhematologic | |||||
| Elevated ALT | — | — | 5 | 1 | |
| Elevated AST | — | — | 1 | 1 | |
| Elevated ALP | — | — | 1 | — | |
| Hyperbilirubinemia | — | — | 1 | — | |
| Abdominal pain | — | 1 | — | — | |
| Diarrhea | — | 1* | 1 | — | |
| Vomiting | — | 1 | — | — | |
| Nausea | 1 | — | — | — | |
| Dehydration | 1 | 1 | 1 | — | |
| Rash | — | 2* | 1 | — | |
| Mucositis | 1 | — | — | — | |
| Dry skin | — | 1 | 1 | — | |
| Hand-foot syndrome | 1 | — | — | — | |
| Anorexia | 2 | 2 | — | — | |
| Fatigue | 5 | — | 1 | — | |
| Hyperglycemia | 1 | — | 1 | — | |
| Insomnia | 1 | — | — | — | |
| Ataxia | 1 | — | — | — | |
| Neuropathy, sensory | — | 1 | — | — | |
| Taste alteration | 1 | — | — | — | |
| Infection | 1 | — | — | — | |
| Hematologic | |||||
| Neutropenia | 2 | 1* | — | — | |
| Lymphopenia | — | 6 | 1 | 4 | |
| Anemia | 1 | — | — | — | |
ALP indicates alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase.
*
Dose-limiting toxicity.