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Types of reactive groups used for targeting of various protease classes.
| Reactive group | Targeted protease class | References |
|---|---|---|
| phosphonate | serine proteases | 6, 67–70 |
| sulfonate | serine proteases | 68 |
| vinyl sulphone | cysteine proteases threonine proteases (proteasome) | 7, 11, 30, 79 |
| epoxide | cysteine proteases | 10, 41–47 |
| diazomethyl ketone | cysteine proteases | 5 |
| acyloxymethyl ketone | cysteine proteases | 9, 89 |
| hydroxamate | metalloproteases | 13, 72–77 |
