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. Author manuscript; available in PMC: 2011 Nov 3.
Published in final edited form as: Cell Metab. 2010 Nov 3;12(5):431–442. doi: 10.1016/j.cmet.2010.09.011

Figure 3. sRA mice are small and lean, primarily due to a large increase in activity-independent energy expenditure.

Figure 3

(A) Body masses of male and female mice from 9–22 weeks of age (Control males N=9, females N=6, sRA males N=6, females N=4). (B) Body masses of mice at day 17 of gestation (Control N=15, sRA N=8), and 4-weeks (Control N=9, sRA N=4), and 8-weeks (Control N=17, sRA N=9) after birth. (C) MRI scans of adult male mice. (D) Hematoxylin & Eosin stained sections of interscapular brown adipose (BAT), and peri-genital and peri-renal white adipose (WAT) from adult mice. Scale bars = 100 microns. (E) Body masses, total 24-hour ad libitum intake of standard chow, and food intake data normalized to body mass (Control N=12, sRA N=8). (F) Core body temperatures determined by telemetric probes (N=6 for all). (G) Spontaneous physical activity determined by telemetric probes. (H) Metabolic rate, determined by indirect calorimetry (N=8 for all). * P<0.05 vs. control. All data are mean ± SEM. See also Figure S3.