Table 2.
Transcription factors regulating biliary development.
| Transcription factors | Functions in IHBD development |
|---|---|
| C/EBPα | Inhibit biliary differentiation; suppress HNF6 and HNF1β expression. (Shiojiri et al., 2004; Yamasaki et al., 2006) |
| FoxA1 | Repress cholangiocyte proliferation. (Li et al., 2009) |
| FoxA2 | Repress cholangiocyte proliferation. (Li et al., 2009) |
| FoxM | Promote biliary differentiation. (Krupczak-Hollis et al., 2004) |
| Hex | Control biliary differentiation and morphogenesis; regulate the expression of HNF4α, HNF1β and HNF6. (Hunter et al., 2007) |
| Hes1 | Promote tubulogenesis and ductal plate remodeling |
| HNF1β | Regulate bile duct morphogenesis. (Coffinier et al., 2002) |
| HNF6 | Regulate biliary differentiation and morphogenesis. (Clotman et al., 2002) |
| OC2 | Promote biliary differentiation; regualte biliary morphogenesis. (Margagliotti et al., 2007) |
| Prox1 | Regulate hepatoblast differentiation. (Dudas et al., 2004) |
| Sox9 | Temporally regulate the completetion of primitive asymmetric duct. (Antoniou et al., 2009) |
| Sall4 | Promote biliary fate determination and inhibit hepatocyte differentiation. (Oikawa et al., 2009) |
| Tbx3 | Inhibit biliary differentiation and promote hepatocyte differentiation. (Suzuki et al., 2008) |