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National Cancer Institute Organ Dysfunction Working Group Criteria for Hepatic Dysfunction
| Marker | Hepatic Function Category |
|||
|---|---|---|---|---|
| Normal | Mild Dysfunction* | Moderate Dysfunction | Severe Dysfunction | |
| Total bilirubin | ≤ ULN | Group 1: ≤ ULN; group 2: > 1.0× to 1.5× ULN | > 1.5× to 3.0× ULN | > 3× ULN |
| AST | ≤ ULN | Group 1: > ULN; group 2: any | Any | Any |
Abbreviation: ULN, upper limit of normal.
Should meet criteria for either group 1 or 2.
