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Identification of Ref-1 as molecular target of AP-1 inhibitor PNRI-299. (a) Affinity purification of proteins using biotinylated compound (162-150) targeting Ref-1 protein, in A549 nuclear lysates. (b) Western blot of Ref-1 in supernatant of A549 nuclear extracts treated with affinity probe 162-150 (50–500 μm) but not 162-149 (50–500 μm) is shown. (c) Cotransfection of Ref-1 expression vector in A549 cells transfected with an AP-1 luc reporter gene construct.
