Figure 2. Phenotypic profiling of aneuploid strains.
(a–b, e–h) Representative images (left) and growth curves (right) under indicated conditions. U1–U3: haploid, diploid and triploid euploid control strains, respectively. (c) Strain positions. A1–A38: aneuploid strains (see Supplementary Figure 4 for their karyotype). P1–4: four petite strains not further studied. (d) One-copy number increase of ATR1 is required and sufficient to confer resistance to 0.4μg/ml 4-NQO. (i) Clustering of strains based on karyotypic similarity. White: euploid chromosome number; red: gain over euploid number; blue: chromosome loss. (j) Clustering of conditions used in phenotypic profiling based on the fitness relative to U1. White: growth similar to U1; red: fitness gain over U1; blue: fitness loss. The strains were ordered as in (i). Scale bar applies to both (i) and (j). Analysis details in Supplementary Methods.