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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Gastroenterology. 2010 Jul 14;139(5):1642–1653.e6. doi: 10.1053/j.gastro.2010.07.008

Figure 3. PI3K p110δD910A/D910A macrophages demonstrate heightened sensitivity to TLR stimulation.

Figure 3

BMMs from WT (black bars) and PI3K p110δD910A/D910A (grey bars) mice were stimulated with TLR9 (CpG), TLR2 (sBLP) or TLR5 (Flagellin) ligands for 24 hours. Supernatants were analyzed for IL-12 p40, IL-12 p70 or IL-23 secretion by ELISA and nitric oxide secretion by Greiss reaction. Error bars represent mean+SEM of 3 independent experiments.