FIG. 8.
Overall structures of Nrf2 and Keap1 showing the different domains. In Nrf2, the DLG motif (amino acids 27–32) and the ETGE motif (amino acids 77–82) of the Neh2 domain comprising the two Keap1-binding sites are indicated and the black bars represent the lysine residues that are ubiquitinated by Cul3-Rbx. The Neh1 and Neh3 domains form the DNA-binding site of the transcription factor. In Keap1, the BTB domain is the dimerization domain and the site of interaction with Cul3. The Kelch domain is the Nrf2-binding domain. The black bars indicate the distribution of the cysteine residues of Keap1.