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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Neuroimage. 2010 Aug 5;54(1):635–644. doi: 10.1016/j.neuroimage.2010.07.070

Table 2.

Activation Foci and Volumes. Location and spatial extent of activated regions based on a voxelwise analysis comparing the Famous and Unfamiliar name conditions (see Methods for details). Activation foci are shown separately for each of the four groups, with Famous > Unfamiliar regions shown in the upper table half and Unfamiliar > Famous regions shown in lower half. Activated regions are depicted in Figure 1.

Low Risk High Risk
Low PA High PA Low PA High PA
Side Region BA x y z vol x y z vol x y z vol x y z vol
Famous > Unfamiliar
Frontal Lobes
 L SFG/MFG 6,8 −28 17 49 4.3
 L SFG/MFG 8,9 −33 38 38 2.2
 R SFG/MFG 4,6,32 30 4 50 1.3
 B SFG/MdFG 8,9 −2 49 44 1.3
 L SFG/MdFG 9,10 −24 63 13 1.1 −6 61 12 0.9
Parietal/Temporal Lobes
 B PC/Precuneus 7,23,31 −2 −58 25 1.3 −3 −52 28 3.6
 R PC/Retrosplenial 23,29,30 10 −48 5 1.3
 L PC/Retrosplenial 23,29,30 −11 −46 3 1.3
 L STG/MTG/AG/SMG 7,22,39,40 −44 −65 29 1.6 −42 −67 30 4.2 −28 −54 28 26.3
 R STG/MTG 22,37,39 52 −53 6 2.1
 L MTG/ITG 21 −54 −22 −11 1.5
Total Volume of Activated Tissue (ml) 4.0 7.8 2.6 39.7
Unfamiliar > Famous
Frontal Lobes
 L PreG/MFG 4,6 −45 −8 44 0.8 −40 −6 47 1.1 −47 −2 40 0.8
 B SMA/MdFG/AC 6,8,24,32 6 4 53 0.8 1 17 44 3.5
 R Insula/IFG 44,45 38 20 10 1.7
Parietal/Temporal Lobes
 L Precuneus/SPL 7 −22 −65 42 1.4
 R Precuneus/SPL 7 24 −58 42 2.1
Occipital Lobes
 R MOG/IOG/LG/FG 18,19 32 −80 1 1.8
 L MOG/IOG/LG/FG 18,19 −37 −71 −9 0.8
Total Volume of Activated Tissue (ml) 1.6 5.8 7.4 0.0

Notes: BA = Brodmann areas; Risk = +/− APOE-ε4; PA = Physical Activity; L = left; R = right, B = bilateral; positive = right (x), anterior (y), and superior (z), representing center of mass in Talairach coordinates; vol = volume in ml; PreG = precentral g.; MFG = middle frontal g.; SFG = superior frontal g.; MdFG = Medial Frontal g.; SMA = supplementary motor area; AC = anterior cingulate; IFG = inferior frontal g.; SPL = superior parietal lobule; PC = posterior cingulate; STG = superior temporal g.; MTG = middle temporal g.; AG = angular g.; SMG = supramarginal g.; MOG = middle occipital g.; IOG = inferior occipital g.; LG = lingual g.; FG = fusiform g.