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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Aug 14;126(4):784–790. doi: 10.1016/j.jaci.2010.07.006

Figure 4. Impaired allergic skin inflammation in response to acute skin challenge with OVA in EC sensitized CRTH2−/− mice.

Figure 4

(A) PGD2 levels in challenged previously unsensitized skin from BALB/c mice previously EC sensitized with OVA. Measurement was performed 24 hrs after tape stripping and challenge with OVA or saline. (B) Representative skin histology. Magnification 200X. (C) Skin infiltrating CD4+ T cells and eosinophils. (D) Q-PCR analysis of mRNA levels of IL-4 and IL-13. Results are expressed as fold induction relative to saline challenged skin of EC sensitized WT mice (n=4–5 mice per group). *p<0.05, **p<0.01.