Table 9.
PLATO bleeding definitions* (modified from CURE definitions)
| Term | Associated with a ↓ in hemoglobin | Transfusion of whole blood or PRBCs for bleeding | |
|---|---|---|---|
| Major bleed—life threatening | Fatal or intracranial or intrapericardial with cardiac tamponade or hypovolemic shock or severe hypotension requiring pressors or surgery | >50 g/L (3.1 mmol/L) | ≥4 units |
| Major bleed—other | Significantly disabling (e.g., intraocular with permanent vision loss) | 30–50 g/L (1.9–3.1 mmol/L) | 2–3 units |
| Minor bleed | Requires medical intervention to stop or treat bleeding | ||
| Minimal bleed | All others not requiring intervention or treatment |
From James et al. [53].
PRBCs, packed red blood cells.
*If the bleeding event fulfills criteria in more than one category, the event will be assigned to the most severe category.