Figure 3.
Antithrombotic effects and bleeding time with (A) ticagrelor, (B) clopidogrel, and (C) compound 072, a chemical compound indistinguishable from prasugrel, in animal models. Left panels: Percent of thrombus size inhibition, percent of arterial blood flow, and n-fold increase in bleeding time versus control according to dose of each drug in anesthetized rat model. Data are mean ± standard error of the mean (SEM); n = 4–6. Right panels: Percent of arterial blood flow, percent of IPA ex vivo, and n-fold increase in blood loss and bleeding time versus control according to dose of each drug in anesthetized dogs. Data are mean ± SEM; n = 6. Adapted with permission from van Giezen et al. [38].