Table 2.
Extracellular Matrix Components of Decellularized Lungs Pre- and Post-Ventilation for 7 Days in Bioreactor System
| Component | Normal lung | Decellularized lung | p-Value | |
|---|---|---|---|---|
| OH-Proline (μg) | Pre | 294.4 ± 55.3 | 246.4 ± 60.1 | 1.8 e −1 |
| Post | 292.8 ± 19.2 | 187.1 ± 27.3a | 5.4 e −3 | |
| Elastin (μg) | Pre | 1218.3 ± 103.7 | 767.8 ± 233.6 | 1.5 e −3 |
| Post | 1896.5 ± 299.8 | 659.2 ± 79.6 | 2.3 e −3 | |
| GAGs (μg) | Pre | 257.6 ± 7.8 | 35.0 ± 40.0 | 7.0 e −4 |
| Post | 176.4 ± 35.3 | 181.6 ± 140.1 | 0.9 e −0 | |
| Laminin (ng) | Pre | 1195.2 ± 379.1 | 698.0 ± 280.0 | 1.6 e −7 |
| Post | 1405.3 ± 19.2 | 594.3 ± 244.2 | 5.7 e −4 | |
| Total protein (mg) | Pre | 38.7 ± 0.8 | 1.9 ± 0.8 | 6.0 e −7 |
| Post | 42.5 ± 2.8 | 3.0 ± 0.9 | 1.9 e −7 |
a
p = 0.16 for decellularized lung pre versus post.
GAGs, glycosaminoglycans.