. Author manuscript; available in PMC: 2010 Sep 23.

Published in final edited form as: Nat Rev Cancer. 2010 Feb;10(2):138–146. doi: 10.1038/nrc2791

Table 1.

Angiocrine factors produced by the vascular niche

Angiocrine factors	Function	Organ specificity	Refs
BMP2 and BMP4	Organogenesis and tumorigenesis	Nonspecific	66
FGF2	Organogenesis and tumorigenesis	Nonspecific	4
BDNF	Neurogenesis	Brain and heart	68
PEDF	Neurogenesis	Brain and bone marrow	67
PGF	Angiogenesis and tumorigenesis	Nonspecific	117
PDGFβ	Angiogenesis and tumorigenesis	Smooth muscle	60,86,118
VEGFA	Angiogenesis and autocrine loop	Vasculature	119
ANGPT2	Angiogenesis remodelling	Vasculature	26
Jagged 1 and jagged 2	Haematopoiesis, angiogenesis and tumorigenesis	Bone marrow	83,110
LAMA4	Organogenesis and tumorigenesis	Stem cell niches	11,62
NO	Tumorigenesis and leukaemogenesis	Nonspecific	76
IL-8, IL-6, CD40, G-CSF, GM-CSF, IGF1, SDF1, EDN1, MCP1 and TGFβ	Tumorigenesis and tissue repair	Nonspecific	60,106

ANGPT2, angiopoietin 2; BDNF, brain-derived nerve growth factor; BMP, bone morphogenetic protein; CSF, colony stimulating factor; EDN1, endothelin 1; FGF, fibroblast growth factor; G-CSF, granulocyte-CSF; GM-CSF, granulocyte-macrophage-CSF; IGF, insulin-like growth factor; IL, interleukin; LAMA4, laminin α4; MCP1, monocyte chemotactic protein 1 (also known as CCL2); NO, nitric oxide; PDGFβ, platelet-derived growth factor-β; PEDF, pigmented epithelial growth factor; PGF, placental growth factor; SDF1, stromal cell-derived factor 1 (also known as CXCL2); TGFβ, transforming growth factor-β; VEGF, vascular endothelial growth factor.