Table 1.
Clinical features, CSF pleocytosis, imaging abnormalities, artery involvement, and virologic findings in patients with varicella zoster virus (VZV) vasculopathy
| Case | Age, y | Sex | Relevant underlying disorders | Rash | CSF pleocytosis | MRI/CT focal lesions | Focal vascular abnormalities* | Artery involvement | CSF VZV | Reduced serum/CSF ratio of VZV IgG | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DNA | IgG | |||||||||||
| 1 | 61 | M | None | + | + | + | + | Mixed | − | + | + | 5 |
| 2 | 18 | F | None | − | + | + | ND | Small | − | + | + | 6 |
| 3 | 54 | M | AIDS | − | + | + | ND | Small | + | + | + | 6 |
| 4 | 34 | M | AIDS | + | + | + | ND | Small | − | + | + | 6 |
| 5 | 42 | M | None | − | + | + | + | Mixed | − | + | + | 7 |
| 6 | 2 | M | None | + | + | + | + | Mixed | − | + | + | 8 |
| 7 | 7 | F | None | + | + | + | + | Mixed | + | − | ND | 9 |
| 8 | 2 | M | None | + | − | + | ND | Mixed | + | − | ND | 10 |
| 9 | 4 | F | None | + | + | + | ND | Small | − | + | + | 11 |
| 10 | 1 | F | None | − | + | + | − | Mixed | − | + | + | 11 |
| 11 | 28 | M | HIV+ | − | + | + | − | Mixed | + | + | + | 12 |
| 12 | 4 | M | None | + | + | + | + | Mixed | − | + | + | 13 |
| 13 | 71 | M | Leukemia | + | − | + | + | Large | − | + | + | 14 |
| 14 | 76 | F | None | + | − | − | − | Small | − | + | + | 14 |
| 15 | 51 | F | CREST syndrome | − | − | + | + | Mixed | − | + | + | 15 |
| 16 | 36 | M | HIV+ | + | + | + | + | Mixed | + | + | + | 16 |
| 17 | 56 | F | None | − | − | + | + | Large | − | + | + | 1 |
| 18 | 77 | F | None | + | − | + | + | Mixed | − | + | + | 1 |
| 19 | 52 | F | None | + | + | + | + | Small | − | + | + | 1 |
| 20 | 52 | M | HIV+ | + | + | + | − | Small | + | + | + | 1 |
| 21 | 76 | F | Lymphoma | − | + | + | − | Small | − | + | + | 1 |
| 22 | 58 | M | None | + | − | + | + | Large | − | + | + | 1 |
| 23 | 88 | M | None | + | + | + | ND | Large | − | + | + | 1 |
| 24 | 54 | F | None | + | − | + | − | Small | − | + | + | Unpublished |
| 25 | 20 | F | None | + | − | + | + | Mixed | + | + | + | Unpublished |
| 26 | 63 | F | None | − | + | + | ND | Small | − | + | + | Unpublished |
| 27 | 25 | F | None | − | − | + | + | Mixed | − | + | + | Unpublished |
| 28 | 73 | M | CLL | + | + | + | + | Mixed | + | + | + | Unpublished |
| 29 | 78 | M | Low C4 | − | + | + | + | Mixed | + | + | + | Unpublished |
| 30 | 63 | F | RA, SLE† | + | + | + | − | Small | − | + | + | Unpublished |
Determined by four-vessel angiography or MRA.
Patient on chronic prednisone and hydroxyurea.
ND = not done; CREST = calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia; CLL = chronic lymphocytic leukemia; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus.