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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nature. 2009 Nov 18;462(7275):880–885. doi: 10.1038/nature08616

Figure 5. Schematic transport mechanism.

Figure 5

Shown is a single transporter protomer. Substrate and sodium binding to the outward and inward facing states is coupled to the closure of the extracellular and intracellular gates, HP2 (red) and HP1 (yellow), respectively. Isomerization between the outward and inward facing occluded states occurs upon movement of the transport domain (blue), relative to the trimerization domain (grey). The inward facing open state has not been structurally characterized and is hypothetical.