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ONOO− directly inhibits the mitochondrial respiratory chain. NO combines with O2− produced by the mitochondrial respiratory chain to form ONOO−, which inhibits the respiratory chain at complex IV, and when reduced glutathione (GSH) levels are low, complex I. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article at www.liebertonline.com/ars).
