Table 1.
Clinical data for 70 symptomatic dengue patients on admission in Martinque*
| Clinical data | NS1 positive (n = 47) | NS1 negative (n = 23) | P† |
|---|---|---|---|
| Plasma virus load × 103 plaque-forming unit equivalent/mL | 13.1 [71.8] | 1.06 [8] | 0.012 |
| Epidemiology | |||
| Age, years | 30 [28] | 32 [25] | 0.837 |
| Male:female | 17:30 | 9:14 | 1 |
| DENV-2:DENV-4 infection | 13:34 | 8:15 | 0.590 |
| Primary:secondary infection | 36:11 | 16:7 | 0.569 |
| Sampled days 1–3:4–6 | 34:13 | 15:8 | 0.586 |
| Vital signs | |||
| Body temperature, °C | 38.7 [1.4] | 38.7 [1.7] | 0.762 |
| Pulse pressure, mm Hg | 48 [24] | 49 [20] | 0.626 |
| Heart rate, beats/minute | 93 [30] | 89 [26] | 0.684 |
| Signs and symptoms, no. (%) | |||
| Headache | 42 (89) | 20 (87) | 1 |
| Retroorbital pain | 18 (41) | 9 (39) | 1 |
| Muscle and/or joint pain | 36 (77) | 15 (68) | 0.559 |
| Backache | 38 (81) | 17 (74) | 0.545 |
| Epigastralgia | 19 (41) | 9 (39) | 1 |
| Gastrointestinal signs | 24 (51) | 12 (52) | 1 |
| Fatigue | 34 (74) | 17 (74) | 1 |
| Cough | 12 (26) | 6 (26) | 1 |
| Rash | 5 (11) | 0 (0) | 0.161 |
| Bleeding | 5 (11) | 3 (13) | 1 |
| Postural hypotension | 5 (11) | 1 (4) | 0.656 |
| Presyncope/syncope | 12 (26) | 5 (22) | 1 |
| Biology | |||
| Hematocrit, % | 39 [6] | 40 [5] | 0.609 |
| Hemoglobinemia, g/L | 134 [26] | 135 [24] | 0.435 |
| Thrombocyte count × 103/mL | 154 [94] | 171 [105] | 0.753 |
| Lymphocyte count/mL | 570 [420] | 595 [340] | 0.355 |
| Neutrophile count/mL | 3,705 [2,530] | 4,580 [2,050] | 0.167 |
| ASAT (U/L | 30 [43] | 43 [44] | 0.270 |
| ALAT (U/L) | 20 [39] | 27 [30] | 0.161 |
| Creatine kinase (U/L) | 135 [235] | 186 [202] | 0.204 |
| Total proteinemia (g/L) | 74 [6] | 72 [5] | 0.565 |
| C-reactive protein (mg/L) | 6.3 [28] | 10.6 [38] | 0.274 |
| Uncomplicated dengue, no. (%) | 34 (69.4) | 16 (69.6) | 1 |
| Hospitalized, no. (%) | 20 (43) | 8 (35) | 0.609 |
*
NS1 = nonstructural protein 1; DENV = dengue virus; AST = aspartate aminotransferase; ALT = alanine aminotransferase. Continuous data are expressed as median [25–75% interquartile range].
†
By Fisher's exact test (categorial data) or Mann-Whitney test (continuous data).