Figure 1.
Coronal microCT-based virtual histology sections of wild-type (WT) mice (A and C) and ApoE null mice (B and D) (28-week-old females). Specimens were stained with a precommercial staining solution (Numira Biosciences, Salt Lake City, Utah) and scanned in a Scanco μCT40 instrument at 6 μm isometric resolution. Insets E, F, G, and H correspond to yellow boxed regions in A, B, C, and D, respectively. Insets of the aortic leaflet (F) and ascending aorta (H) demonstrate atherosclerotic plaques (bracketed by yellow lines) in the ApoE null mice. Bar=1 mm.