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. Author manuscript; available in PMC: 2010 Aug 26.
Published in final edited form as: Annu Rev Biophys. 2009;38:347–369. doi: 10.1146/annurev.biophys.35.040405.102118

Figure 6.

Figure 6

Effect of phosphorylation on smooth muscle myosin regulatory light chain (RLC) structure. (a) EPR from site-directed spin labeling; the sequence dependence of accessibility changes dramatically, implying a transition from disorder to helical order (49). (b) Structural model. Blue, myosin heavy chain. Red, RLC (25–168) from crystal structure (PDB ID 1SEM). Purple, RLC (1–24), based on FRET (66), EPR (49), and molecular dynamics simulation (20, 21), showing that phosphorylation induces a disorder-to-order transition in the N-terminal domain of RLC.