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TICCs are activated by inositol 1,4,5-trisphosphate receptor (IP3R)-dependent sarcoplasmic reticulum (SR) Ca2+ release. A: representative trace and summary data of TICC activity in the presence of extracellular Ca2+ (n = 6) and at 30 s (n = 6) and ∼5 min (n = 6) after extracellular Ca2+ is removed. B: representative trace and summary data of TICC activity in the presence of the sarco(endo)plasmic Ca2+-ATPase pump blocker cyclopiazonic acid (CPA, 10 μM, n = 5). *P < 0.05 vs. control.
