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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Neurosci Lett. 2010 Mar 1;473(3):242–247. doi: 10.1016/j.neulet.2010.02.058

Figure 4.

Figure 4

5α, 3α-THDOC direct activation and potentiation of α6β2δ receptors

(A) Wild-type α6β2δ (left) or chimeric α6β2×δ (right) receptors were exposed to EC20 GABA or EC20 GABA plus 1 μM 5α, 3α-THDOC. Concentration-response plots of 5α, 3α-THDOC direct activation (as a proportion of EC20 GABA current; B) and potentiation of EC20 GABA currents (C). As in Fig. 2B, the rising and falling phases of the bell-shaped curves are plotted separately (upper and lower traces, respectively). Statistical significance (wild-type vs. chimera; P < 0.05) is indicated by * (Student's T test) or # (Mann-Whitney test); n = 9 for wild-type, n=3 for chimera.