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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Clin Cancer Res. 2010 Jul 2;16(16):4217–4225. doi: 10.1158/1078-0432.CCR-10-0777

Fig. 1. Apoptosis induced by ABT-737 and ABT-263 in purified CLL cells.

Fig. 1

A, CLL cells freshly isolated from peripheral blood of CLL patients were incubated in RPMI + 10% FCS with different concentrations of ABT-737 or ABT-263 for 4 h before apoptosis was assessed by externalization of phosphatidylserine (PS) and staining with AnnexinV-FITC (n=21, *=P<0.05). B, the half maximal effective concentration (EC50) values for ABT-737 and ABT-263 were calculated with GraphPad Prism and compared for each patient. C, the chemical structures of ABT-737 and ABT-263 are shown. Position 1, 2, and 3 indicate the 4-chlorobiphenyl, arylnitro and dimethylamino groups of ABT-737, respectively.