Table 1.
Summary of ROI results. Regions listed were defined from an omnibus Task>Rest contrast and tested for proximity to threat, line condition, and anxiety effects within 2 (line type; SELF vs. OTHER) × 4 (proximity to threat; LOW, MEDIUM, HIGH, SHOCK) ANOVAs with anxiety as a continuous covariate. Values denote significance levels for main effects of proximity to threat and anxiety and the proximity to threat by anxiety interaction. No region demonstrated a significant main effect of line type, though the left insula trended toward greater response to the SELF relative to OTHER line (p=0.06), see Figure 5. P-values marked with • denote those exceeding Bonferroni-adjusted alpha correcting for number of regions tested.
| Region | Talairach Coordinates | Proximity to threat | Anxiety | Proximity to threat x anxiety | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Left amygdala | −33 | −7 | −15 | 0.024 | -- | -- |
| Right amygdala | 27 | −7 | −17 | -- | -- | -- |
| Left VBF/BNST | −9 | 0 | −8 | <0.001• | 0.007 | 0.012 |
| Right VBF/BNST | 12 | −1 | −10 | -- | -- | -- |
| Left DLFPC (BA44) | −53 | 10 | 33 | <0.001• | -- | <0.001• |
| Right DLPFC (BA44) | 53 | 13 | 24 | <0.001• | -- | 0.002• |
| Left insula | −36 | 17 | −8 | -- | -- | -- |
| Right insula | 45 | 20 | −11 | <0.001• | -- | 0.004• |
| DMPFC (BA8) | 6 | 37 | 40 | <0.001• | -- | -- |