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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: Nature. 2007 Jul 1;448(7153):553–560. doi: 10.1038/nature06008

Figure 5. H3K4me3 and H3K36me3 annotate genes and non-coding RNA transcripts.

Figure 5

(a) Foxp1 has two annotated promoters (based on RefSeq and UCSC Known Genes), only one of which shows H3K4me3 in ES cells. The corresponding transcriptional unit is marked by H3K36me3. In MEFs, H3K36me3 extends an additional 500 kb upstream to an H3K4me3 site that appears to reflect an alternate promoter (this site is bivalent in ES cells). (b) H3K36me3 enrichment extends significantly downstream of Sox2. Though highly active in ES cells, Sox2 is flanked by two bivalent CpG islands that may poise it for repression. (c) H3K4me3 and H3K36me3 indicate two highly expressed non-coding RNAs, and (d) the putative primary transcript (dashed line) for a single annotated microRNA.