Table 6.
Odds ratios and 95% CIs of Pancreatic Cancer according to Baseline Anthropometric Factors by Gender, the PanScan Consortium, Females
| Characteristic | Cases | Controls | OR (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| 1064 | 1086 | Model 1a | Model 2b | Model 3c | Model 4d | Model 5e | |
| BMI, kg/m2, cohort- and gender specific quartiles | |||||||
| Q1 | 249 | 280 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Q2 | 249 | 267 | 1.07 (0.83-1.36) | 1.06 (0.82-1.36) | 1.11 (0.84-1.48) | 1.07 (0.82-1.39) | 1.08 (0.79-1.47) |
| Q3 | 266 | 275 | 1.13 (0.89-1.44) | 1.08 (0.85-1.39) | 1.24 (0.94-1.64) | 1.10 (0.85-1.43) | 1.16 (0.85-1.57) |
| Q4 | 300 | 264 | 1.34 (1.05-1.70) | 1.19 (0.93-1.53) | 1.37 (1.03-1.81) | 1.39 (1.08-1.80) | 1.52 (1.11-2.10) |
| P trend | 0.01 | 0.17 | 0.02 | 0.008 | 0.007 | ||
|
| |||||||
| BMI, kg/m2, categories | |||||||
| Underweight (<18.5 kg/m2) | 14 | 20 | 0.75 (0.37-1.51) | 0.72 (0.35-1.48) | 0.65 (0.29-1.44) | 0.68 (0.29-1.55) | 0.45 (0.16-1.29) |
| Normal (≥18.5 and <25.0 kg/m2) | 433 | 500 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Overweight (≥25.0 and <30.0 kg/m2) | 365 | 333 | 1.31 (1.07-1.60) | 1.27 (1.03-1.55) | 1.40 (1.12-1.76) | 1.30 (1.05-1.61) | 1.34 (1.04-1.72) |
| Obese (≥30.0 kg/m2) | 173 | 174 | 1.19 (0.93-1.54) | 1.12 (0.87-1.46) | 1.23 (0.92-1.64) | 1.25 (0.96-1.63) | 1.29 (0.93-1.79) |
| Severely obese (≥35.0) | 79 | 59 | 1.61 (1.12-2.33) | 1.29 (0.88-1.89) | 1.50 (0.98-2.30) | 1.65 (1.13-2.40) | 1.98 (1.17-3.36) |
| P trend | 0.003 | 0.08 | 0.01 | 0.002 | 0.001 | ||
|
| |||||||
| Weight, kg, cohort- and gender specific quartiles | |||||||
| Q1 | 265 | 285 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Q2 | 235 | 276 | 0.92 (0.72-1.18) | 0.93 (0.73-1.20) | 0.89 (0.67-1.18) | 0.94 (0.72-1.21) | 0.86 (0.62-1.18) |
| Q3 | 279 | 269 | 1.14 (0.90-1.46) | 1.12 (0.87-1.43) | 1.16 (0.88-1.52) | 1.18 (0.91-1.52) | 1.14 (0.84-1.54) |
| Q4 | 285 | 256 | 1.23 (0.96-1.56) | 1.12 (0.87-1.44) | 1.27 (0.96-1.68) | 1.24 (0.96-1.61) | 1.34 (0.98-1.84) |
| P trend | 0.03 | 0.22 | 0.03 | 0.03 | 0.02 | ||
|
| |||||||
| Height, cm, cohort- and gender specific quartiles | |||||||
| Q1 | 338 | 330 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Q2 | 245 | 255 | 0.91 (0.72-1.16) | 0.89 (0.70-1.14) | 0.89 (0.67-1.17) | 0.89 (0.69-1.15) | 0.79 (0.57-1.09) |
| Q3 | 248 | 265 | 0.89 (0.71-1.13) | 0.92 (0.72-1.17) | 0.95 (0.73-1.24) | 0.89 (0.69-1.14) | 0.98 (0.73-1.32) |
| Q4 | 233 | 236 | 0.92 (0.72-1.17) | 0.95 (0.74-1.21) | 0.95 (0.72-1.25) | 0.89 (0.69-1.16) | 0.85 (0.63-1.16) |
| P trend | 0.45 | 0.69 | 0.80 | 0.38 | 0.52 | ||
|
| |||||||
| Waist circumference, cohort- and gender specific quartilesf | |||||||
| Q1 | 147 | 162 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Q2 | 117 | 143 | 0.89 (0.64-1.25) | 0.92 (0.66-1.30) | 0.81 (0.56-1.16) | 0.85 (0.60-1.22) | 0.77 (0.51-1.14) |
| Q3 | 153 | 148 | 1.14 (0.83-1.58) | 1.14 (0.82-1.58) | 1.08 (0.76-1.54) | 1.12 (0.80-1.57) | 1.14 (0.77-1.68) |
| Q4 | 173 | 147 | 1.31 (0.95-1.80) | 1.26 (0.91-1.75) | 1.28 (0.91-1.80) | 1.24 (0.88-1.73) | 1.17 (0. 79-1.73) |
| P trend | 0.04 | 0.09 | 0.06 | 0.10 | 0.19 | ||
|
| |||||||
| Waist-to-hip ratio, cohort- and gender specific quartilesf | |||||||
| Q1 | 119 | 143 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Q2 | 120 | 131 | 1.14 (0.80-1.63) | 1.21 (0.84-1.74) | 1.15 (0.78-1.68) | 1.20 (0.83-1.75) | 1.20 (0.80-1.82) |
| Q3 | 126 | 154 | 0.96 (0.67-1.36) | 0.94 (0.66-1.34) | 0.96 (0.66-1.39) | 0.92 (0.63-1.33) | 0.97 (0.64-1.47) |
| Q4 | 163 | 109 | 1.87 (1.31-2.69) | 1.85 (1.27-2.69) | 1.77 (1.20-2.61) | 1.95 (1.33-2.86) | 1.61 (1.03-2.50) |
| P trend | 0.003 | 0.008 | 0.01 | 0.005 | 0.11 | ||
Adjusted for cohort, age (categorical), anthropometry source (self-reported, measured), and smoking (never, former, current).
Adjusted for cohort, age (categorical), anthropometry source (self-reported, measured), smoking (never, former, current), and diabetes history (no, yes).
Adjusted for cohort, age (categorical), anthropometry source, smoking, and excluding the first 2 years of follow-up.
Adjusted for cohort, age (categorical), anthropometry source, and excluding current and former smokers.
Adjusted for cohort, age (categorical), anthropometry source, and excluding the first 2 years of follow-up, current and former smokers, and people with diabetes.
Models for waist circumference and waist-to-hip ratio were additionally adjusted for height.
NOTE: Statistically significant results are in bold.