Fig. 4. Genetic interaction of Brpf1 and Moz and rescue of the brpf1 mutant phenotype by TSA treatment.
(A–H) Synergistic enhancement of phenotypes caused by partial loss of Brpf1 and Moz. hoxa2b (A–D; 35 hpf) and bapx1 (E–H; 52 hpf) in situ hybridizations of zebrafish larvae after single or double injections of low amounts of MOs, as indicated in upper right corners. Lateral views. Arrow in D points to absent hoxa2b expression in CNC. Arrow in H indicates ectopic bapx1 expression domain in arch 2. (I–L) Rescued hoxa2b expression in the brpf1 mutant (−/−) after TSA treatment (compare L with K), whereas expression in treated wild-type siblings remains largely unaltered (compare J with I).