Skip to main content
. Author manuscript; available in PMC: 2010 Aug 4.
Published in final edited form as: Nat Rev Cancer. 2008 Sep;8(9):714–724. doi: 10.1038/nrc2401

Figure 2. Influence of RB loss: context dependence.

Figure 2

a | RB loss leads to diverse outcomes, such as hyperplasia or genome instability, in different cellular and tissue contexts. b | A diverse class of signals leads to the dephosphorylation and activation of RB. Activated RB can mediate cell-cycle inhibition leading to quiescence and/or dormancy or senescence. With the loss of RB, it is possible to escape cell-cycle inhibition and progress to either proliferation or apoptotic cell death.