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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Gen Comp Endocrinol. 2010 Mar 23;170(1):3–17. doi: 10.1016/j.ygcen.2010.03.013

Figure 3.

Figure 3

Role of the thyroid hormone (TH)-induced immediate early transcription factor Krüppel-like factor 9 (KLF9) in TH receptor (TR) autoinduction. Ligand-bound TR-retinoid X receptor (RXR) heterodimers bind to and induce expression of klf9 and trb genes. The upregulation of KLF9 by TH precedes TRβ. KLF9 associates with the promoter region of TRβ and enhances TRβ autoinduction (Bagamadbad et al., 2008). Aside from being a TH direct target gene, klf9 is also a direct glucocorticoid receptor (GR) target gene that is induced by stress (Bonett et al., 2009; P. Bagamasbad, T. Ziera, S.A. Borden and R.J. Denver, unpublished data). Thyroid hormone and glucocorticoids synergistically activate KLF9 expression, thereby further enhancing TRβ autoinduction.