Figure 3. Multiple Ca sources contribute to synaptic Ca signaling.
(a) Uncaging-evoked uEPSPs (upper two traces) and associated ΔCasp (lower two traces) produced by single or triple (50 Hz) uncaging pulses are illustrated. Mean (black solid lines) and mean ± SEM (shaded regions) are shown for responses evoked in the presence of the NMDAR antagonist CPP (n=21). Light gray shaded regions indicate the mean ± SEM responses under control conditions, reproduced from Fig. 2.
(b) Traces are arranged as in (a) for responses evoked in selective VGCC blockers as indicated above each column: mibefradil (Mib, n=18), SNX-482 (SNX, n=20), ω-agatoxin IVA (Aga, n=24), ω-conotoxin GVIA (GVIA, n=26), nimodipine (Nim, n=26). Light gray shaded regions indicate the mean ± SEM responses under control conditions.
(c) Population data for peak uEPSP, expressed as a percentage of the control value, for each stimulus and condition illustrated in (a) and (b).
(d) Population data for ΔCasp, expressed as a percentage of the control value, for each stimulus and condition illustrated in (a) and (b).
* indicates a significant difference (p<0.05).