Table 2.
List of clusters where adolescents with MDD had significantly lower FA (p<0.001, uncorrected) compared to the healthy group. Bold rows correspond with brain images displayed in Figure 1. IFOF=Inferior Fronto-occipital fasciculus, SLF=Superior Longitudinal Fasciculus; MDD = Major Depressive Disorder; MNI = Montreal Neuroimaging Institute; FA = Fractional Anisotropy
| No. voxels |
MNI coordinates |
Hemisphere | White Matter Tract | Corresponding cortical area(s) | Tmax value | Cohen d | FA values Mean (S.D.) Healthy/Control |
|---|---|---|---|---|---|---|---|
| 13 | −37, 18,35 | Left | No label | Middle frontal | 4.05 | 0.93 | .28 (.11)/ .20 (.07) |
| 10 | 28,−70,14 | Right | IFOF | Occipital (Cuneous) |
3.61 | 1.48 | .68 (.04)/ .60 (.06) |
| 10 | −22,23,−5 | Left | Uncinate | Orbitofrontal | 4.12 | 1.47 |
.46 (.04)/ .40 (.04) |
| 9 | 32,30,−6 | Right | IFOF/Uncinate |
Orbitofrontal cortex, insula |
4.11 | 1.89 |
.37 (.07)/ .25 (.05) |
| 7 | −28,−71,1 | Left | IFOF | Occipital | 3.82 | 1.68 | .65 (.05)/ .58 (.04) |
| 7 | 26,17,−7 | Right | Uncinate | Orbitofrontal cortex, insula |
4.07 | 1.44 | .52 (.05)/ .45 (.05) |
| 6 | 24,−56,31 | Right | IFOF | Parietal cortex (Precuneous) |
3.60 | 1.09 | .41 (.06)/ .35 (.06) |
| 6 | −15,45,25 | Left | Cingulum |
Medial frontal |
3.91 | 1.39 |
.45 (.05)/ .39 (.04) |
| 5 | −47,−39,8 | Left | SLF | Temporal | 3.63 | 1.28 | .48 (.06)/ .41 (.06) |
| 5 | 37,−62,−4 | Right | IFOF | Occipital | 4.02 | 0.68 | .43 (.09)/ .38 (.08) |