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. Author manuscript; available in PMC: 2010 Jul 22.
Published in final edited form as: Mol Cell. 2005 Dec 22;20(6):939–949. doi: 10.1016/j.molcel.2005.10.023

Figure 2.

Figure 2

Crystal structure of MC159. A. MC159 tetramer structure from the P2221 crystal form, shown in cyan, magenta, yellow and green, respectively for each monomer. B. Stereo ribbon drawing of the high-resolution structure of MC159 from the P212121 crystal form. DED1 is shown in cyan and DED2 in magenta. Helices H0–H7 of DED1 and H1–H6 of DED2 are labeled. H3 is absent in DED1. C. Electrostatic surface representation of MC159, showing the dumbbell shaped structure and the rich charges on one face of MC159. The top panel is related to B by an approximate 180° rotation along the vertical axis followed by a 90° rotation on the page. The lower panel is related to B by an approximate 90° rotation on the page. D. Stereo cylinder drawing, showing the superposition of MC159 DED1 (cyan) with FADD DED (red) and DED2 (magenta) with FADD DED (yellow). For the superposition between DED1 and FADD, helices H0 and H7 are only present in DED1, while H3 is only present in FADD. E. Stick model for the hydrogen bonding interactions in the charge triad of DED1.