Table 2.
Relationship Between Allele Frequencies for Single Nucleotide Polymorphisms in Age-Related Macular Degeneration-Associated Genes (CFH, LOC387715, C2, C3, APOE, and TLR3) and the Progression of Geographic Atrophy (Mean Growth Rate, mm2, per Year)a
| Allele | N=114 eyes of 114 patients | Mean | Standard error | p-value | Bonferroni adjusted p-value | |
|---|---|---|---|---|---|---|
| CFH | T | 79 | 1.78 | 0.103 | ||
| rs1061170 | C | 129 | 1.96 | 0.083 | 0.17 | 1 |
| LOC387715 | G | 115 | 1.65 | 0.088 | ||
| rs10490924 | T | 97 | 2.09 | 0.102 | 0.001 | 0.011 |
| C2 | G | 224 | 1.91 | 0.063 | ||
| rs9332739 | C | 2 | 1.58 | 0.989 | 0.62 | 1 |
| C3 | G | 150 | 1.84 | 0.074 | ||
| rs2230199 | C | 78 | 1.99 | 0.116 | 0.27 | 1 |
| APOE | C | 200 | 1.88 | 0.065 | ||
| rs7412 | T | 26 | 2.10 | 0.218 | 0.26 | 1 |
| APOE | C | 207 | 1.92 | 0.066 | ||
| rs429358 | T | 19 | 1.66 | 0.187 | 0.24 | 1 |
| TLR3 | G | 154 | 1.89 | 0.079 | ||
| rs3775291 | A | 64 | 1.96 | 0.111 | 0.64 | 1 |
a
There were no adjustments necessary for the following variables: Age, body mass index (BMI), education, treatment, gender, smoking, and family history, each of which was non-significant.