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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Cancer Res. 2010 May 11;70(10):4112–4122. doi: 10.1158/0008-5472.CAN-09-4244

Figure 4. Deletion of Wip1 enhanced basal and IR-induced γ̃H2AX levels in cells undergoing oncogenic stress.

Figure 4

A) Immunocytochemistry of Wip1-/- E1A/Ras MEFs showed enhanced basal γ̃H2AX levels compared to wt E1A/Ras MEFs in the absence of p-ATM staining. B) Immunoblot analysis of γ-H2AX showed that Wip1-/- E1A/Ras MEFs had elevated γ-H2AX levels basally and after IR at the indicated time points compared to the wild type control (“wt E1A/Ras MEFs”). ERK2 is used as a loading control.