FIG. 2.
Attachment of viruses with altered receptor specificity to tissues of the human upper and lower respiratory tract. The attachment pattern of viruses NL03 (H3N2) and IND05 (H5N1) and the three mutant viruses IND05-HAN182K, IND05-HAQ222L,G224S, and IND05-HAN182K,Q222L,G224S to human nasal turbinates, trachea, bronchus, bronchiole, and alveoli was determined. Virus attachment is shown in red. The panels were chosen to reflect the attachment pattern in the whole tissue section as much as possible, but small differences between the single panels and overall view may exist.