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. Author manuscript; available in PMC: 2011 Mar 11.
Published in final edited form as: Cell Cycle. 2010 Mar 11;9(5):930–936. doi: 10.4161/cc.9.5.10931

Figure 2. A mechanism for ATM activation.

Figure 2

STEP 1: Following DSB production, MRN is recruited to DSB. In parallel, HP1 proteins are released from H3K9me3, and either retained on the chromatin, or released to the nucleoplasm by a process involving phosphorylation of HP1 by the CK2 kinase 91. It is not know if MRN participates in this process. STEP 2: Inactive ATM-Tip60 complex is recruited to the DSB by MRN, facilitating interactions between Tip60's chromodomain and H3K9me3. STEP 3: Interaction between MRN and ATM, in combination with acetylation of ATM by Tip60, activates ATM's kinase activity. Me = methylation, Ac = acetylation, P = phosphorylation.