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. 2010 Jul 5;207(7):1453–1464. doi: 10.1084/jem.20091474

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© 2010 Sander et al.

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Figure 2. — Mobilization and splenic accumulation of CD11b⁺Gr1⁺ MDSCs are impaired in gp130Δhepa mice. (A) Representative flow cytometric analysis and (B) graphic analysis of CD11b⁺Gr1⁺ cell frequencies in bone marrow, peripheral blood, and spleens in gp130f/f and gp130Δhepa mice at the indicated time points after CLP (n = 5–12 per time point per group; pooled data of 12 independent experiments). #, gp130f/f did not survive to 7 and 10 d in sufficient numbers and could therefore not be included in the analysis. (C) Immunofluorescence staining of spleen sections for CD11b (red, CD11b; blue, DAPI) to show infiltration of myeloid cells after induction of sepsis. Spleens were explanted at the indicated time points. Bars, 100 µm. ***, P < 0.001. Data are presented as means ± SEM. n.d., not determined.