Figure 5.
Drug induced catecholamine concentration transients in the rostral and caudal NAc shell after raclopride (2 mg/kg, i.p.) and cocaine (15 mg/kg, i.p.). Two-dimensional color plot representation of the background-subtracted cyclic voltammograms collected over 30 sec (A) before and (B) following administration of drugs in the rostral and caudal NAc shell. Catecholamine concentration changes are apparent in the color plots (B) at the potential for its oxidation (~ 0.65 V) and its reduction (−0.2 V). Principal component regression was used to extract the time course of the catecholamine concentration transients (lower traces in A and B). Times are indicated by the vertical bars. Inset: Cyclic voltammograms recorded at the time indicated by the arrows were identical to those for a catecholamine.