Fig. 3.
Response to a hyperpolarizing voltage ramp is compared for a living interneuron and the Full and Reduced Models, in 0 Ca2+, Cs+ saline (neurons) or simulated with Ca and h conductances set to 0 (models). Vm is the command voltage during somatic voltage-clamp. Im is the voltage-clamp current. Conductance amplitudes in the Full Model (black) were tuned to match voltage-ramp current to examples from living neurons, such as the one shown in blue. When the Full Model was reduced and scaled to preserve input resistance (Passively Reduced Model) (red, dashed line), the holding current changed only slightly. When the Passively Reduced Model was rescaled to match active properties (Actively Reduced Model) (green), the input resistance decreased slightly, indicated by the steeper ramp current.