Fig 6.
Keap1+-tumors had a reduction in cell proliferation and an induction of apoptosis in response to cisplatin treatment. (A) Protein levels of Nrf2 and Keap1-CBD in tumor tissues. Each lane contained the tumor tissue lysate extracted from individual mouse. Three tumor tissues per group were used for the immunoblot analysis. (B) Reduced Nrf2 expression in Keap1+-tumors was confirmed by IHC staining. (C) Keap1+ tumor tissues had reduced proliferation in response to cisplatin treatment, as measured by IHC-Ki67. (D) Keap1+ tumor tissues had reduced proliferation in response to cisplatin treatment, as measured by TUNEL staining.