Table 1.
Median effect values of MLN8237 in MM cell lines
| Cell line | Dm, μM (median effective dose) |
|
|---|---|---|
| Cell viability | Cell proliferation | |
| MM1.S | 0.13 | 0.006 |
| OPM1 | 0.03 | 0.003 |
| RPMI 8226 | 10.32 | 0.004 |
| INA6 | 0.002 | 0.0002 |
| OPM2 | 4.37 | 1.71 |
| MM1.R | 1.68 | 0.04 |
| DOX40 | 5.48 | 0.10 |
| LR5 | 2.53 | 0.009 |
| U266 | 1.43 | 0.08 |
Half-maximal effect values (Dm) of MLN8237 in each MM cell line were determined using CalcuSyn software, Version 2.0 (Biosoft). MM cells were incubated in the absence or presence of MLN8237 at the indicated concentrations (0.0001-4μM) for 72 hours. Dm values were determined using cell viability and cell proliferation data.