Skip to main content
. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: J Am Chem Soc. 2008 Jan 25;130(7):2336–2343. doi: 10.1021/ja078223d

Table 7.

Relative Rates of Incorporation and Extension for dSICS and dMMO2 analogsa

Relative Rate of
Incorporationb 		Relative Rate of
Extensionc
X Y dXTP
:dY 		dYTP:
dX 		X:Y Y:X
graphic file with name nihms211675t1.jpg SICS MMO2 1 1 1 1
graphic file with name nihms211675t2.jpg ICS MMO2 0.10 0.03 1.82 0.01
graphic file with name nihms211675t3.jpg SPYR MMO2 0.01 0.26 0.28 0.08
graphic file with name nihms211675t4.jpg SNICS MMO2 ndd ndd 0.50 0.06
graphic file with name nihms211675t5.jpg 5SICS MMO2 3.13 1.06 0.6 1.1
graphic file with name nihms211675t6.jpg SICS 2OMe 1.10 1.26 1.82 2.44
graphic file with name nihms211675t7.jpg SICS DM5 1.50 0.38 0.66 0.03
graphic file with name nihms211675t8.jpg SICS 4MP 0.01 0.03 0.04 1.00
graphic file with name nihms211675t9.jpg SICS MM3 ndd ndd 0.05 0.02
a

Relative rates are defined as the ratio of the second order rate constants of the X:Y pair to the SICS:MMO2 pair. Changes in rate greater than 10-fold are italicized. See supporting information for experimental details.

b

Incorporation of dXTP against dY or dYTP against dX.

c

Extension of X:Y or Y:X. Bases are listed primer:template.

d

not determined.