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Steady State Rate Constants of Self-Pair Synthesis by Incorporation of dXTP against dX for SICS and analogsa
| 5' – dTAATACGACTCACTATAGGGAGA | |||
|---|---|---|---|
| 3' – dATTATGCTGAGTGATATCCCTCT(X)GCTAGGTTACGGCAGGATCGC | |||
| X |
kcat (min−1) |
KM (µM) |
kcat/KM (M−1min−1) |
| SICSb | 5 ± 1 | 3.2 ± 3.1 | 1.6 × 06 |
| 4SICS | 2.6 ± 0.8 | 8.6 ± 1.7 | 3.0 × 105 |
| 5SICS | 1.7 ± 0.5 | 63 ± 4 | 2.7 × 104 |
See Experimental Section for experimental details.
Ref 23.
