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. 2010 Jun 9;11(6):532–542. doi: 10.1016/j.cmet.2010.04.014

Figure 1.

Figure 1

PYY-Positive L Cells in WT and NPY−/− Mouse Colon and Gpr119 Responses in WT Mouse Intestinal Mucosa

(A) Immunohistochemical localization showing distinct PYY-containing L cells in WT and NPY−/− mucosae, but not in PYY−/− or NPYPYY−/− mouse descending colon. Scale bar, 20 μm throughout.

(B) Example Gpr119 responses to apical (Ap) or basolateral (Bl) PSN632408 (10 μM). The basal Isc levels are shown to the left of each trace, and mucosal area was 0.14 cm2.

(C) Tissue sensitivity to apical PSN632408 (10 μM) in mouse mucosae from duodenum (D), jejunum (J), mid and terminal ileum (MI, TI), and ascending (AC) and descending colon (DC). Data are the mean − SEM from 3–14 observations. Background information, including basal electrophysiological parameters, is presented in Table S1. The pharmacology of selected Y agonist responses in WT versus null mouse colon mucosae are compared in Figure S1, with the patterns of NPY immunoreactivity in WT and null tissues presented in Figure S2.